Invasive Aspergillosis Animal Models (IAAM) Contract
SPECIFIC AIMS of this contract are:
1) to establish and standardize animal models of invasive aspergillosis including murine and larger animal species with both pulmonary and disseminated infection;
2) to develop molecular tools utilizing genomic information that will provide standardized procedures for conducting genetic manipulation of Aspergillus strains that can be tested in animal model systems for the purpose of identifying new diagnostic targets or tools.
3) to determine gene expression of both whole cell and individual target genes of Aspergillus in experimental infection;
4) to utilize genomic data to develop novel diagnostic and immunologic
5) to utilize the genetically manipulated Aspergillus strains to assess pathogenicity and virulence in animal models of infection to determine how new diagnostics perform over the course of disease;
6) to provide a mechanism for disseminating knowledge and skills obtained from this effort to other interested scientists and laboratories and effectively interact with the extended Aspergillus community (academia as well as commercial interests) to develop new diagnostic tools. (click link to see a recent presentation from the 2006 Advances Against Aspergillosis meeting )
Essential Criteria for Aspergillus Diagnostics
As a service to the Aspergillus research community, the University of Texas Health Science Center at San Antonio will provide companies and academic investigators with samples, including validated positive and negative controls, to validate Aspergillus diagnostic assays.
Additionally, once IAAM contract investigators have identified promising diagnostic target assays, they will be interested in working with commercial organizations to bring these assays to market for use in clinical diagnostic settings.
For more information about obtaining samples or commercial partnering opportunities, please contact:
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