Publications:
  • Lopez-Ribot, J.L. and W.L. Chaffin. 1996. Members of the Hsp70 family of proteins in the cell wall of Saccharomyces cerevisiae. J. Bacteriol. 178:4724-4726.

  • Lopez-Ribot, J.L., H.M. Alloush, B.J. Masten, and W.L. Chaffin. 1996. Evidence for presence of a protein related to the Hsp70 familiy in the cell wall of Candida albicans. Infect. Immun. 64:3333-3340.

  • Alloush, H.M., J.L. Lopez-Ribot, B.J. Masten, and W.L. Chaffin.1997. 3-phosphoglycerate kinase: a glycolytic enzyme present in the cell wall of Candida albicans. Microbiology. 143:321-330.

  • Lopez-Ribot, J.L. P. Sep™lveda, A.M. Cervera, P. Roig, D. Gozalbo, and J.P. MartÌnez. 1997. Cloning of a cDNA fragment encoding part of the protein moiety of the 58 kDa fibrinogen-binding mannoprotein of Candida albicans. FEMS Microbiol. Lett. 157:273-278.

  • Lopez-Ribot, J.L., R.K. McAtee, L.N. Lee, W.R. Kirkpatrick, T.C. White, D. Sanglard, and T.F. Patterson. 1998. Distinct patterns of gene expression associated with the development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob. Agents Chemother. 42:2932-2937.

  • MartÌnez, J.P., M.L. Gil, J.L. Lopez-Ribot, and W. L. Chaffin. 1998. Serologic response to cell wall proteins and mannoproteins of Candida albicans. Clinical Microbiology Reviews. 11:121-141.

  • Chaffin, W.L., J.L. Lopez-Ribot, M. Casanova, D. Gozalbo, and J.P. MartÌnez. 1998. Cell wall and secreted proteins of Candida albicans: identification, function and expression. Microbiology and Molecular Biology Reviews. 62:130-180.

  • Lopez-Ribot, J.L.,Ý W.R. Kirkpatrick, R.K. McAtee, R. LaValle and T.F. Patterson 1999. Low levels of antigenic variability in fluconazole-susceptible and -resistant Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Clin. Diag. Lab. Immunol. 6:665-670.

  • Lopez-Ribot, J.L., R.K. McAtee, S. Perea, W.R. Kirkpatrick, M.G. Rinaldi and T.F. Patterson. 1999. Multiple resistant phenotypes coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 43:1621-1630.

  • Lopez-Ribot, J.L, J. Bikandi, R. San Millan, and W. L. Chaffin. Interactions between Candida albicans and the human extracellular matrix component Tenascin-C. Molecular Celll Biology Research Communications. In press.

Awards, Recognitions and other Professional Activities:

Predoctoral Fellowship, Spanish Ministry of Science and Education, 1989-1991
Cum laude  in Doctoral Thesis. School of Pharmacy, Univ. of Valencia, 1991
Premio extraordinario de doctorado (Special Recognition Award for Doctorate), Univ. of Valencia, 1993
NATO Postdoctoral Fellowship, 1995
Member IACUC Committee, UTHSCSA, 1999-2003
Member Intellectual Property Committee, UTHSCSA, 2002-2005
Co-chair, Intellectual Property Committee, UTHSCSA, 2004-2005
Member Institutional Biosafety Committee, UTHSCSA, 2003-2005
Chair, Institutional Biosafety Committee, UTHSCSA, 2004-2005
Chair, Institutional Biosafety Committee, UTSA, 2005-present
Scientific Advisory Committe, MHCOE, UTHSCSA
Member of the Organizing Committee, XV Congress of the International Society for Human and Animal Mycology, San Antonio, May 2003. (Scientific Program Committee)
Burroughs Wellcome Fund New Investigator in Molecular Pathogenic Mycology, 2001      
Associate Editor, Revista Iberoamericana de Micologia
Editorial Board, Infection and Immunity (2004-2007)
Editorial Board, Current Immunology Reviews (2005-)
Ad-hoc reviewer for the following journals: Proteomics, Eukaryotic Cell, Molecular Microbiology, Microbiology, Medical Mycology, Clinical Infectious Diseases, Journal of Infectious Diseases, Current Biology, Journal of Clinical Microbiology, Antimicrobial Agents and Chemotherapy, Canadian Journal of Microbiology, PNAS, FEMS Immunology and Medical Microbiology, Current Genetics, Journal of Antimicrobial Chemotherapy, Food Microbiology, Vaccine, BioMed Central-Microbiology, Chemistry and Biology, Fungal Genetics and Biology, FEMS Microbiology Letters, Microbes and Infection.

Permanent member, NIH Bacteriology and Mycology-2 Study section (2003-2004)
Permanent member, NIH Pathogenic Eukaryotes (PTHE) Study section (2004-2007)
Ad-hoc reviewer for Granting Agencies: NIH (AARR-4, NIDCR Special Grants Review and bacterial pathogenesis), National Science Foundation (NSF), Department of Defense (DoD), Veteran’s Administration Merit Review, Health Research Council of New Zealand, Fondo Nacional de Ciencia  Tecnica, Agencia Nacional Promocion Cientifica y Tecnologica, Argentina, The Wellcome Trust (UK), Department of Health Policy Research Programme (UK), Research Council of Hong Kong, Research Funding and Policy Division, Health Research Board (Ireland), British Society for Antimicrobial Chemotherapy (UK).
Professional Memberships: Sociedad Española de Microbiologia (SEM, Spanish Society for Microbiology), American Society for Microbiology (ASM), Texas Branch of the ASM, Medical Mycological Society of the Americas (MMSA), Asociacion Española de Micologia (AEM), European Confederation of Medical Mycology (ECMM), International Society for Human and Animal Mycology (ISHAM), Hispanic Faculty Association at UTHSCSA.

Research Support.

Ongoing:
National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). " NRG1 regulation of Candida albicans virulence".  R03 AI 054447. Dates: 04/01/2003 to 03/31/2005 (no cost extension to 3/31/06). The main objective of this small grant is to assess the virulence of our genetically engineered strain in a murine model of disseminated candidiasis. Role: PI

National Institute of Dental and Craneofacial Research (NIDCR), National Institutes of Health (NIH). "Analysis of the Candida albicans proteome".  R21 DE 15079. Dates: 08/01/2003 to 07/31/2005 (no cost extension to 6/06). The main objective of this exploratory and developmental grant is to generate a C. albicans proteomic database. Role: PI


Completed:
Burroughs Wellcome Fund New Investigator in Molecular Pathogenic Mycology. “Gene and Protein Expression Profiling in Candida albicans biofilms”. Dates: 07/2001-06/2004. These project uses genomic and proteomic approaches to study the C. albicans biofilm life-style. Role: PI

Inhibitex Inc. Development of immune-based strategies against candididiasis. Dates: 02/01/2002-01/31/2004. The main objective is to develop monoclonal antibodies for the therapy of candidiasis. Role: PI

National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). "Protective antibodies to Candida albicans mp58".  R29 AI 42401. Dates: 05/01/97 to 04/31/03. The main objective of this project is to identify protective antibody responses during systemic candidiasis. Role: PI

Texas Higher Education Coordinating Board. Advanced Technology Program  (Biomedicine). "Exploring the Phenotypic Traits Associated with the Formation of Candida albicans Biofilms". 003659-0080-1999. Dates: 01/01/00-08/01/02. The main objective of this project is to develop models and analyze characteristics of C. albicans biofilms. PI

American Heart Association, Texas Affiliate. “Phage Display Shot-Gun Cloning of Candida albicans adhesins for extracellular matrix”. Dates: 07/01/00-06/30/02. The main objective of this project is to develop and use C. albicans genomic phage-display libraries for the cloning of candidal adhesins. Role: PI

Merck. "Activity of Caspofungin against Candida albicans Biofilms". Dates: 07/01/2001-06/30/2002. The main objective of this project is to evaluate the activity of caspofungin (a new echinocandin) against Candida biofilms. Role: PI.

National Institute of Dental and Craneofacial Research (NIDCR), National Institutes of Health (NIH). Thomas F. Patterson P.I. "Fluconazole Resistance in Oropharyngeal Candidiasis". 2 R01 DE11381-04A2. Dates: 03/01/00-02/28/03 (no cost extension taken). This is a continuation (years 4, 5 and 6) of a grant to evaluate fluconazole resistance in HIV-infected patients with OPC.  Role: Co-Investigator.

 

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