Research Objectives/Areas of Interest:

1. Study of antifungal activity of newer drugs against common nosocomial, as well as rare and emerging fungi.
2. Study of the epidemiology and diagnosis of fungal colonization and infection in burn patients.
3. Study of the operating characteristics of currently available diagnostic systems in the diagnosis of fungal infections.

FUNGAL PUBLICATIONS

Books

• Hospenthal DR, Rinaldi MG, eds. Diagnosis and Treatment of Human Mycoses. Totowa, NJ: Humana Press; 2008:1-428.

Peer-reviewed Publications

• Hospenthal DR, Rogers AL, Mills GL. Development of amphotericin B liposomes bearing antibody specific to Candida albicans. Mycopathologia 1988;101:37-45.
• Hospenthal DR, Rogers AL, Beneke ES. Effect of attachment of anticandidal antibody to the surfaces of liposomes encapsulating amphotericin B in the treatment of murine candidiasis. Antimicrob Agents Chemother 1989;33:16-18.
• Hospenthal D, Gretzinger K, Rogers A. Treatment of a murine model of systemic candidiasis with Liposomal amphotericin B bearing antibody to Candida albicans. J Med Microbiol 1989;30:193-197.
• Belay T, Hospenthal DR, Rogers AL, Patterson MJ. Evaluation of antibody-bearing Liposomal amphotericin B in the treatment of systemic candidiasis in a neutropenic murine model. J Med Vet Mycol 1991;29:419-421.
• Hospenthal D, Belay T, Lappin P, Rogers A, Kennedy M. Disseminated trichosporonosis in a neutropenic murine model. Mycopathologia 1993;122:115-122.
• Belay T, Hospenthal DR, Rogers AL, Patterson MJ. Treatment of systemic candidiasis in a neutropenic murine model using immunoglobulin G bearing liposomal amphotericin B. Mycopathologia 1993;123:9-17.
• Byrd JC, Hargis JB, Kester KE, Hospenthal DR, Knutson SW, Diehl LF. Opportunistic pulmonary infections with fludarabine in previously treated patients with low-grade lymphoid malignancies: a role for Pneumocystis carinii pneumonia prophylaxis. Am J Hematol 1995;49:135-142.
• Hospenthal DR, Byrd JC, Weiss RB. Successful treatment of invasive aspergillosis complicating prolonged treatment-related neutropenia in acute myelogenous leukemia with amphotericin B lipid complex. Med Pediatr Oncol 1995;25:119-122.
• Hospenthal DR, Hicks CB, Green DL, Wiesen AR, Byrd JC, Isenbarger DW, Salzberg DJ. Trends in the incidence and diversity of fungi recovered from urine. Mycopathologia 1995;132:15-19.
• Hospenthal DR, Kwon-Chung KJ, Bennett JE. Concentrations of airborne Aspergillus compared to the incidence of invasive aspergillosis. lack of correlation. Med Mycol 1998;36:165-168.
• Hospenthal DR, Bennett JE. Flucytosine monotherapy for cryptococcosis. Clin Infect Dis 1998;27:260-264.
• Park MK, Hospenthal DR, Bennett JE. Treatment of hydrocephalus secondary to cryptococcal meningitis with shunting. Clin Infect Dis 1999;28:629-633.
• Radkar G, Hospenthal D. Unusual presentation of pulmonary coccidioidomycosis in a traveler. Hawaii Med J 2000;59:2380239.
• Hospenthal DR, Bennett JE. Persistence of cryptococcomas on neuroimaging.  Clin Infect Dis 2000;31:1303-1306.
• Perfect JR, Cox GM, Lee JY, Kauffman CA, de Repentigny L, Chapman SW, Morrison VA, Pappas P, Hiemenz JW, Stevens DA, Mycoses Study Group. The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis. Clin Infect Dis 2001;33:1824-1833. [study group member]
• Hospenthal DR, Murray CK, Beckius ML, Green JA, Dooley DP. Persistence of pigment production by yeasts grown on CHROMagar Candida. J Clin Microbiol 2002;40:4768-4770.
• Mora-Duarte J, Betts R, Rotstein C, Colombo AL, Thompson-Moya L, Smietana J, Lupinacci R, Sable C, Kartsonis N, Perfect J, Caspofungin Invasive Candidiasis Study Group. Comparison of caspofungin and amphotericin B for invasive candidiasis. N Engl J Med 2002;347:2020-2029. [study group member]
• Horvath LL, Hospenthal DR, Murray CK, Dooley DP. Direct isolation of Candida spp. from blood cultures on CHROMagar Candida. J Clin Microbiol 2003;41:2629-2632.
• Horvath LL, Hospenthal DR, Murray CK, Dooley DP. Detection of simulated candidemia by the BACTEC 9240 with Plus Aerobic/F and Anaerobic/F blood culture bottles. J Clin Microbiol 2003;41:4714-4717.
• Horvath LL, George BJ, Murray CK, Harrison LS, Hospenthal DR. Direct comparison of the BACTEC 9240 and BacT/ALERT 3D automated blood culture systems for Candida growth detection. J Clin Micrbiol 2004;42:115-118.
• Hsue G, Napier JT, Prince RA, Chi J, Hospenthal DR. Treatment of meningeal coccidioidomycosis with caspofungin. J Antimicrob Chemother 2004;54:292-294.
• George BJ, Horvath LL, Hospenthal DR. Effect of inoculum size on detection of Candida growth by the BACTEC 9240 automated blood culture system using aerobic and anaerobic media. J Clin Microbiol 2005;43:433-435.
• Halsey ES, Rasnake MS, Hospenthal DR. Coccidioidomycosis of the male reproductive tract. Mycopathologia 2005;159:199-204.
• Murray CK, Beckius ML, Green JA, Hospenthal DR. Use of chromogenic media in the primary isolation of yeasts from clinical specimens. J Med Microbiol 2005;54:981-985.
• Hospenthal DR, Beckius ML, Floyd ML, Horvath LL, Murray CK. Presumptive identification of Candida species other than C. albicans, C. krusei, and C. tropicalis with the chromogenic medium CHROMagar Candida. Ann Clin Microbiol Antimicrob 2006;5:1.
• Hamilton BG, Humphreys CW, Conner WC, Hospenthal DR. Allergic bronchopulmonary disease secondary to Bipolaris spicifera: Case report. J Bronchol 2006;13:77-79.
• Schofield CM, Murray CK, Horvath EE, Cancio LC, Kim SH, Wolf SE, Hospenthal DR. Correlation of culture and histopathology in fungal burn wound colonization and infection. Burns 2007;33:341-346.
• Horvath EE, Murray CK, Vaughan GM, Chung KK, Hospenthal DR, Wade CE, Holcomb JB, Wolf SE, Mason AD, Cancio LC. Fungal wound infection (not colonization) is independently associated with mortality in burn patients. Ann Surg 2007;245:978-985.73.
• Horvath LL, George BJ, Hospenthal DR. Detection of fifteen species of Candida in an automated blood culture system. J Clin Microbiol 2007;45:3062-3064.
• Rivard RG, McCall S, Griffith ME, Hawley JS, Ressner RA, Borra H, Moon JE, Beckius ML, Murray CK, Hospenthal DR. Efficacy of caspofungin and posaconazole in a murine model of disseminated Exophiala infection. Med Mycol 2007;45:685-689.
• Okulicz JF, Rivard RG, Conger NG, Nguyen MX, Hospenthal DR. Primary isolation of Candida species from urine specimens using chromogenic media. Mycoses 2008;51:141-146.
• Murray CK, Loo FL, Hospenthal DR, Cancio LC, Jones JA, Kim SH, Holcomb JB, Wade CE, Wolf SE. Incidence of systemic fungal infection and related mortality following severe burns. Burns epub 4 August 2008

Book Chapters/Reviews

• Hospenthal DR, Rogers AL. Immunology of Fungal Infection. In: Borgers M, Hay R, Rinaldi MG, eds. Current Topics in Medical Mycology. Vol. 6. Barcelona: Prous Science; 1995:127-188.
• Hospenthal DR, Bennett JE. A review of current therapy for superficial and deep fungal infections. Contemp Intern Med 1998;10:42-52.
• Hospenthal DR, Bennett JE. Entomophthoramycosis, lobomycosis, rhinosporidiosis, and sporotrichosis. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases. Principles, Pathogens, & Practice. Philadelphia: Churchill Livingstone; 1999:665-671.
• Hospenthal DR, Bennett JE. Miscellaneous fungi and Prototheca. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 5th Ed. Philadelphia: Churchill Livingstone; 2000:2772-2780.
• Hospenthal DR, Bennett JE. Entomophthoramycosis, lobomycosis, rhinosporidiosis, and sporotrichosis. In: Guerrant RL, Walker DH, Weller PF, eds. Essentials of Tropical Infectious Diseases. Philadelphia: Churchill Livingstone; 2001:311-314.
• Hospenthal D. ID: Introduction to fungal infections (mycoses). ID: Blastomycosis (North American blastomycosis, Gilchrist disease). ID: Coccidioidomycosis (valley fever, desert rheumatism). ID: Histoplasmosis (Darling’s disease). ID: Paracoccidioidomycosis (South American blastomycosis). In: Special Operations Forces Medical Handbook. Jackson, Wyoming: Teton NewMedia; 2001.
• Hospenthal D, Schissel D. ID: Candidiasis (thrush). In: Special Operations Forces Medical Handbook. Jackson, Wyoming: Teton NewMedia; 2001.
• Hospenthal DR. Rhinosporidiosis. In: Medicine, Ob/Gyn, Psychiatry, and Surgery. eMedicine Online Textbook, eMedicine World Medical Library, www.emedicine.com. [June 2001]
• Arsura EL, Kilgore WB, Hospenthal DR. Coccidioidomycosis (infectious diseases). In: Medicine, Ob/Gyn, Psychiatry, and Surgery. eMedicine Online Textbook, eMedicine World Medical Library, www.emedicine.com. [January 2002]
• Hospenthal D. ID: Introduction to fungal infections (mycoses). ID: Blastomycosis (North American blastomycosis, Gilchrist disease). ID: Coccidioidomycosis (valley fever, desert rheumatism). ID: Histoplasmosis (Darling’s disease). ID: Paracoccidioidomycosis (South American blastomycosis). In: Special Operations Forces Medical Handbook (CD-ROM). Jackson, Wyoming: Teton NewMedia; 2002.
• Hospenthal D, Schissel D. ID: Candidiasis (thrush). In: Special Operations Forces Medical Handbook (CD-ROM). Jackson, Wyoming: Teton NewMedia; 2002.
• Hospenthal DR, Bennett JE. Fungal infections of the gastrointestinal tract. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL, eds. Infections of the Gastrointestinal Tract. 2nd Ed. Philadelphia: Lippincott Williams & Wilkins; 2002:847-858.
• Davis KA, Hospenthal DR. Candidiasis. In: Gates RH, ed. Infectious Disease Secrets. 2nd Ed. Philadelphia: Hanley and Belfus; 2003:178-183.
• Horvath LL, Hospenthal DR. Sporotrichosis. In: Gates RH, ed. Infectious Disease Secrets. 2nd Ed. Philadelphia: Hanley and Belfus; 2003:197-199.
• Hospenthal DR, Rinaldi MG. Approach to rare and emerging mycoses in patients with hematologic malignancies. Rev Clin Exp Hematol 2003;7(Suppl 1):49-64.
• Hospenthal DR. Mycotoxins. In: Roy MJ, ed. Physician's Guide to Terrorist Attack. Totowa, NJ: Human Press; 2003:189-196.
• Hospenthal DR, Murray CK, Rinaldi MG. The role of antifungal susceptibility testing in the therapy of candidiasis. Diagn Microbiol Infect Dis 2004;48:153-160.
• Hospenthal DR. Management of candidiasis. Infect Med 2004;21:265-267.
• Hospenthal DR. Echinocandin antifungal drugs. Infect Med 2004;21:476-478.
• Hospenthal DR. Agents of chromomycosis. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 6th Ed. Philadelphia: Elsevier; 2005:2988-2991.
• Hospenthal DR. Agents of mycetoma. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 6th Ed. Philadelphia: Elsevier; 2005:2991-2995.
• Hospenthal DR. Uncommon fungi. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 6th Ed. Philadelphia: Elsevier; 2005:3068-3079.
• Hospenthal DR. Voriconazole. Infect Med 2005;22:84-87.
• Arsura EL, Hospenthal DR. Coccidioidomycosis (infectious diseases). In: Medicine, Ob/Gyn, Psychiatry, and Surgery. eMedicine Online Textbook, eMedicine World Medical Library, www.emedicine.com. [May 2005]
• Conger NG, Hospenthal DR. Current therapy of onychomycosis. Infect Med 2005;22:280-283.
• Rivard RG, Hospenthal DR. Rhinosporidiosis. In: Medicine, Ob/Gyn, Psychiatry, and Surgery. eMedicine Online Textbook, eMedicine World Medical Library, www.emedicine.com. [August 2005; updated May 2007]
• Hospenthal DR, Bennett JE. Entomophthoramycosis, lobomycosis, rhinosporidiosis, and sporotrichosis. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases. Principles, Pathogens, & Practice. 2nd Ed. Philadelphia: Churchill Livingstone; 2006;950-956.
• Hawley JS, Hospenthal DR. Fungal Infections of the CNS. Part 1: Meningitis. Infect Med 2005;22:573-576.
• Hospenthal DR. Histoplasmosis. In: Kelley PW, ed. Military Preventive Medicine: Mobilization and Deployment. Vol. 2. In: Textbooks of Military Medicine. Washington, DC: Office of The Surgeon General at TMM Publications, Borden Institute; 2005:1073-1078.
• Hawley JS, Hospenthal DR. Fungal Infections of the CNS. Part 2: Brain abscess. Infect Med 2006;23:185-188.
• Hospenthal DR. Histoplasmosis. In: Burg FD, Ingelfinger JR, Polin RA, Gershon AA, eds. Current Pediatric Therapy. 18th Ed. Philadelphia: Elsevier; 2006:832-835.
• Jacobson EJ, Baum SE, Hospenthal DR. Serologic diagnosis of the endemic mycoses. Infect Med 2006;23:473-479.
• Horvath LL, Hospenthal DR. Community-acquired fungal respiratory infections. In: McCue J, Kahan S, eds. In A Page Infectious Disease. Lippincott Williams & Wilkins; 2007:40-41.
• Ressner RA, Hospenthal DR. Phaeohyphomycosis (Infection due to the dark-walled fungi). Infect Med 2007;24:45-48a.
• Murray CK, Hospenthal DR. Approach to patients with suspected fungal infections. In: Hospenthal DR, Rinaldi MG, eds. Diagnosis and Treatment of Human Mycoses. Totowa, NJ: Humana Press; 2008:3-12.
• Hospenthal DR. Coccidioidomycosis. In: Rakel RE, Bope ET, eds. Conn's Current Therapy 2008. Philadelphia: Saunders Elsevier; 2008;241-243.
• Murray CK, Hospenthal DR. Burn wound infections. In: Medicine, Ob/Gyn, Psychiatry, and Surgery. eMedicine Online Textbook, eMedicine World Medical Library, www.emedicine.com. [April 2008]
• Hospenthal DR. Preface. Pulmonary fungal Infections. Semin Respir Crit Care Med 2008:29;101-102.
• D'Avignon LC, Schofield CM, Hospenthal DR. Pneumocystis pneumonia. Semin Respir Crit Care Med 2008;29:132-140.
• Horvath LL, Hospenthal DR. Coccidioidomycosis. In: Rakel RE, Bope ET, eds. Conn's Current Therapy 2009. 61th Ed. Philadelphia: Elsevier; 2009 accepted for publication
• Hospenthal D. ID: Introduction to fungal infections (mycoses). ID: Candidiasis (thrush). ID: Blastomycosis (North American blastomycosis, Gilchrist disease). ID: Coccidioidomycosis (valley fever, desert rheumatism). ID: Histoplasmosis (Darling’s disease). ID: Paracoccidioidomycosis (South American blastomycosis). In: Special Operations Forces Medical Handbook. 2nd Ed. Jackson, Wyoming: Teton NewMedia; 2008
• Hospenthal DR. Paracoccidioidomycosis. In: Medicine, Ob/Gyn, Psychiatry, and Surgery. eMedicine Online Textbook, eMedicine World Medical Library, www.emedicine.com. [2008]
• Baddley JW, Knox KS, Hospenthal DR, Wheat LJ. Endemic mycoses in the immunocompromised host. In: Rubin RH, Young LS, eds. Clinical Approach to Infection in the Compromised Host. 5th Ed. New York: Springer-Verlag; accepted for publication
• Hospenthal DR. Agents of chromomycosis. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 7th Ed. Philadelphia: Elsevier; accepted for publication
• Hospenthal DR. Agents of mycetoma. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 7th Ed. Philadelphia: Elsevier; accepted for publication
• Hospenthal DR. Uncommon fungi. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 7th Ed. Philadelphia: Elsevier; accepted for publication